Translational Science Director Immunology Cell Therapy
Accountabilities:
As a Translational Science Director, you will be responsible for the design and implementation of translational and biomarker objectives for cellular therapies for immune-mediated diseases as well as operational aspects of clinical biomarker implementation and academic teamwork. Your focus will be on ensuring effective collaborations between research and development, leading interactions between academic collaboration, establishing strong target-to-disease connections, differentiating AZ cellular therapeutics, and driving translational understanding of clinical trial data. You will work with team translational leads to oversee translational studies and deliverables with CROs and collaborators to support new and ongoing clinical studies as well as to enable our LCM strategy. You will be recognized as an authority in translational science and work on difficult drug projects and complex scientific problems, providing solutions that are highly innovative.
Essential Skills/Experience:
- PhD or MD-PhD degree required. Degree or training in Immunology preferred.
- 8 or more years of industry experience with at least 5 years of combined academic/industry experience in clinical development or translational science.
- Experience leading and running academic collaborations including timelines and budget for data and analytical delivery.
- Solid understanding of the pathogenesis of immune mediated disease and the application of cellular, molecular technologies and models to drive program decisions, including those related to supporting value propositions.
- Experience in clinical biomarker development (assay development and validation) of T-cell therapy and/or other advanced therapeutic modalities for Phase 1 studies and beyond.
- Prior experience in BM, precision medicine, IND filings, and deliverables for CSRs and other regulatory filings.
- Proven ability to learn new information rapidly and effectively.
- Demonstrated experience in selecting and handling CROs for translational studies and biomarkers for clinical trials.
- Experience in the authoring of relevant sections regulatory documents.
- Understanding of the full drug development process and critical translational biology needs at each developmental stage.
- Detailed understanding of translational and clinical research methodology and biostatistics principles.
- Understanding of FDA, EMA, MHRA and ICH GCP guidelines.
- Attention to detail, strive to generate high-quality work, and sense of passion and urgency to achieve team and program goals.
- Demonstrated experience contributing to and leading complex clinical stage projects.
- Demonstrated track record in delivering results.
- Outstanding verbal and written communication skills.
- Excellent analytical, problem solving and strategic planning skills.
At AstraZeneca, we are at the cutting-edge of science, rethinking the future of medicine. We work on ground-breaking medicine discovery and development from early to late stage, answering some of the most complex unmet patient needs. We are never complacent about scientific discovery and development. Here we are always pushing our efficiency, searching for knowledge and the next breakthrough. We fully embrace a safe space, exercising our freedom to discover and share. You're supported by the team where setbacks are seen as learning opportunities.
Take the lead to make a bigger impact! Here we need leadership at every level. Physicians who not only have expertise but also the ability to build a business case, engage with partners, and communicate effectively with different audiences. With that kind of remit comes great responsibility and the opportunity to make a big impact. Join us and be a part of our journey in transforming lives with science!
Date Posted
26-Jun-2025Closing Date
Our mission is to build an inclusive and equitable environment. We want people to feel they belong at AstraZeneca and Alexion, starting with our recruitment process. We welcome and consider applications from all qualified candidates, regardless of characteristics. We offer reasonable adjustments/accommodations to help all candidates to perform at their best. If you have a need for any adjustments/accommodations, please complete the section in the application form. ]]>AstraZeneca embraces diversity and equality of opportunity. We are committed to building an inclusive and diverse team representing all backgrounds, with as wide a range of perspectives as possible, and harnessing industry-leading skills. We believe that the more inclusive we are, the better our work will be. We welcome and consider applications to join our team from all qualified candidates, regardless of their characteristics. We comply with all applicable laws and regulations on non-discrimination in employment (and recruitment), as well as work authorisation and employment eligibility verification requirements.
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